The Maxillofacial Center for Diagnostics & Research

Epithelial Dysplasia of the Head & Neck

Bibliography, Abstracts & Select Reviews


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Leukoplakia

 Epithelial Dysplasia

  Smokeless Tobacco Keratosis

Oral Cancer

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Definition: Epithelial dyplasia refers to microscopic alterations of epithelial cells and tissue from normal toward the appearance of cells and tissue usually seen in cancers arising from that epithelium.  The term cellular atypia is sometimes used for the same purpose.  These abnormal cells can be found in precancers as well as cancers, and some of the alterations may be seen in benign and innocuous epithelium, such as regenerating epithelium on the edge of an ulcer or wound.  


Epithelial Dysplasia of the Head & Neck

Table of Contents:

Clinicopathologic studies of oral carcinoma in situ & dysplasia
Epidemiology of H&N dysplasia and carcinoma in situ
Dysplasia in mucosa adjacent to H&N carcinoma
Treatment of dysplasia and carcinoma in situ
Laryngeal carcinoma in situ and dysplasia

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Clinicopathologic Studies of Oral Carcinoma in situ and Epithelial Dysplasia

Rubin IC. The pathologic diagnosis of incipient carcinoma of the uterus. Am J Obstet 1910; 62:668-676.

Darier J, Lemaitre F, Monier L. Les modes de debut des cancers de la bouche et des machiores. Bull Cancer (Paris) 1924; 13:256-272.

Broders AC. Carcinoma in situ contrasted with benign penetrating epithelium. J Am Med Assoc 1932; 99:1670-1674.

Mincer HH, Coleman SA, Hopkins KP. Observations on the clinical characteristics of oral lesions showing histologic epithelial dysplasia. Oral Surg Oral Med Oral Pathol 1972; 33: 389-399.

Kramer IRH. Carcinoma in situ of the oral mucosa. Int Dent J 1973; 23:94-______.

Waldron CA, Shafer WG. Leukoplakia revisted: a clinicopathologic study of 3256 oral leukoplakias. Cancer 1975; 36:1386-1392.

Banoczy J, Csiba A. Occurrence of epithelial dysplasia in oral leukoplakia: analysis and follow-up study of 120 cases. Oral Surg Oral Med Oral Pathol 1976; 42:766-774.

WHO Collaborating Centre for Oral Precancerous Lesions. Definitions of leukoplakia and related lesions: an aid to studies on oral precancers. Oral Surg Oral Med Oral Pathol 1978; 46:518-539.

Santa Cruz DJ. Skin. In: Henson DE, Albores-Saavedra J. The pathology of incipient neoplasia. Philadelphia: W. B. Saunders, 1986:5-16.

Crissman JD, et al. Preinvasive lesions of the upper aerodigestive tract: histologic definitions and clinical implications (a symposium). Pathol Annu 1987; 22:311-352.

McCance DJ, Kopan R, Fuchs E, et al. Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc Natl Acad Sci USA 1988; 85:7169-7173.

Bouquot JE, Ephros H. Erythroplakia -- the dangerous red mucosa. Prac Perio Aesth Dent 1995; 7:59-68.

Lumerman H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol 1995; 79:321-329.

Neville B, Damm D, Allen C, et al. Oral and maxillofacial pathology. Philadelphia: W. B. Saunders, 1995: 284-288.

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Epidemiology of Head & Neck Dysplasias & Carcinoma in situ

Bouquot JE. Epidemiology. In: Gnepp DG. Pathology of the head and neck. New York: Churchill Livingstone, 1987, pp 263-314.

Bouquot JE, Gnepp D. Epidemiology of carcinoma in situ of the upper aerodigestive tract. Cancer 1988; 61: 1685-1690.

Bouquot JE, Kurland LT, Weiland LH. Carcinoma in situ of the upper aerodigestive tract: incidence, time trends and follow-up in Rochester, Minnesota, 1935-1984. Cancer 1988; 61:1691-1698.

Bouquot JE, Weiland LH, Kurland LT. Laryngeal keratosis and carcinoma in the Rochester, Minnesota population, 1935-1984. Cancer Detect Prevent 1991; 15:83-91.64. Myerson MC. Smoker's larynx: clinical pathologic entity. Ann Otol Rhin Laryng 1950; 59:541-546.

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Dysplasia in Mucosa Adjacent to Head & Neck Carcinoma

Wright A, Shear M. Epithelial dysplasia immediately adjacent to oral squamous cell carcinoma. J Oral Pathol 1985; 14:559-564.

Bouquot JE, Weiland LH, Kurland LT. Leukoplakia and carcinoma in situ synchronously associated with invasive oral/pharyngeal carcinoma in Rochester, Minnesota, 1935-1984. Oral Surg Oral Med Oral Pathol 1988; 65:199-207.

Bouquot JE, Gnepp DR. Laryngeal precancer--a review of the literature, commentary and comparison with oral leukoplakia. Head Neck 1991; 13: 488-497.

Slaughter DP, Southwick HW, Smejkal W. "Field cancerization" in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer 1953; 6:963-968.

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Treatment of Epithelial Dysplasis & Carcinoma in situ

Vedtofte P, Holmstrup P, Hjorting-Hansen E, et al. Surgical treatment of premalignant lesions of the oral mucosa. Int J Oral Maxillofac Surg 1987; 16:656-664.

Amagasa T, Yakoo E, Sato K, et al. A study of the clinical characteristics and treatment of oral carcinoma in situ. Oral Surg Oral Pathol Oral Pathol 1985; 60:50-55.

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Laryngeal Carcinoma in situ & Epithelial Dysplasia

Altman F, Ginsberg I Stout AP. Intraepithelial carcinoma (carcinoma in situ) of the larynx. Arch Otolaryngol 1952; 56:121-133.

Pene F, Fletcher GH. Results in irradiation of the in situ carcinoma of the vocal cords. Cancer 1976; 37:2586-2590.

Doyle PJ, Flores A, Douglas GS. Carcinoma in situ of the larynx. Laryngoscope 1977; 87:310-316.

Gabriel CE, Jones DG. Hyperkeratosis of the larynx. J Laryngol Otol 1973; 87:129-134.

McGavran MH, Bauer WC, Ogura JH. Isolated laryngeal keratosis--its relation to carcinoma of the larynx based on a clinicopathologic study of 87 consecutive cases. Laryngoscope 1960; 70:932-951.

Miller AH, Fisher HR. Clues to the life history of carcinoma in situ of the larynx. Laryngoscope 1971; 81:1475-1480.

Elman AJ, Goodman M, Wang CC, et al. In situ carcinoma in the vocal cords. Cancer 1979; 43:2422-2428.

Hellquist H, Lundgren J, Olofsson J. Hyperplasia, keratosis, dysplasia, and carcinoma in situ of the vocal cords -- a follow-up study. Clin Otolaryngol 1982; 7:11-27.

Norris CM, Peale AR. Keratosis of the larynx. J Laryngol Otol 1973; 77:635-647.

Hojslet et al.[1989, find this]

Hintz BL, Kagon AR, Nussbaum H, et al.A "watchful waiting" policy for in situ carcinoma of the vocal cords. Arch Otolaryngol 1981; 107; 746-751.

Kleinsasser O. Uber den Krankheitsverlauf bei Epithelhyperplasien der Kehlkopfscheimaut und die Entstehung von Karzinomen: IV. Mitteilung. Z Laryngol Rhinol Otol 1963; 42:541-558.

Bouquot JE, Weiland LH, Kurland LT. Laryngeal keratosis and carcinoma in the Rochester, Minnesota population, 1935-1984. Cancer Detect Prevent 1991; 15:83-91.64. Myerson MC. Smoker's larynx: clinical pathologic entity. Ann Otol Rhin Laryng 1950; 59:541-546.

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