The following lists and tables of data have been compiled in the hopes that it will be useful to those seeking information pertaining to diseases of the oral and maxillofacial region. We have tried to be as accurate as possible, but you are responsible for proper use of the information. References to the source of the data can be found by clicking on the "References" button associated with the table.
Table 5a: Malignant transformation rates (%) of the largest leukoplakia follow-up studies from Europe and the United States, ranked by sample size (modified from Bouquot JE, Whitaker SB. Quint Internat 1994; 25:133-140).
|
Author(s) |
Country | # Pts. | Cumulative Years of Follow-up | Malignant Transformation Potential |
Annual Cancer Rate |
| Einhorn, Wersall (1967) | Sweden | 782 | 9,149 p-y (mean: 11.7yrs) |
4.0% | 0.34% |
| Banoczy (1977) | Hungary | 670 | 6,566 p-y (mean: 9.8 yrs) |
6.0 | 0.61 |
| Bouquot, et al (1988) * | U.S.A. | 463 | 6,720 p-y (mean: 11.8 yrs) |
10.3 | 0.82 |
| Roed-Peterson (1971) | Denmark | 331 | 1,423 p-y (mean: 4.3 yrs) |
3.6 | 0.82 |
| Leonardelli, Talamazzi (1950) | Italy | 268 | 1,340 p-y (mean: n/a) |
19.8 | 0.40 |
| Silverman et al (1984) | U.S.A. | 257 | 1,850 p-y (mean: n/a) |
17.5 | 0.24 |
| Pindborg, et al (1968) | Denmark | 248 | 918 p-y (mean: 3.7 yrs.) |
4.4 | 1.20 |
| Maerker, Burkhardt (1978) | Germany | 200 | 1,000 p-y (mean: 5.0 yrs) |
12.0 | 2.40 |
| Kramer, et al (1970) | England | 187 | 935 p-y (mean: n/a) |
4.8 | 0.96 |
| Sturgis, Lund (1934) | U.S.A. | 143 | 715 p-y (mean: 5.0 yrs) |
13.0 | 2.37 |
| Total | 3,549 | 30,616 person-years |
8.1% | **1.07% |
* includes 13
cases from the pharynx.
** weighed for different sample
sizes; many studies include a disproportional sampling of high risk lesions;
the overall malignant
transformation rate is usually
considered to be 4-6% when all lesions are assessed.