Dr. Bouquot's Papers: Maxillofacial Osteonecrosis

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Massive ischemic damage to this mandible is represented by irregular brownish, mushy areas of marrow, including that of the condyle.  Notice the many cystic spaces and areas of marble-like ischemic osteosclerosis.

The Maxillofacial Center, 165 Scott Avenue, Suite 100, Morgantown, WV 26508 USA
Phone: 304-292-4429   Fax: 304-291-5149    Email: MFC@aol.com


Published Research & Review Papers
[click on underlined author's name for more detail]

Bouquot JE, Roberts AM, Person P, Christian J. NICO (neuralgia-inducing cavitational osteonecrosis): osteomyelitis in 224 jawbone samples from patients with facial neuralgia. Oral Surg Oral Med Oral Pathol 1992; 73:307-319.

Bouquot J. In review of NICO (neuralgia-inducing cavitational osteonecrosis), the invisible "osteomyelitis" of the jaws. Proceedings of Parker Mahan International Conference on Facial Pain. Pantke Institute, Gainesville, Florida; April, 1994.

Bouquot J, Christian J. Long-term effects of jawbone curettage on the pain of facial neuralgia. J Oral Maxillofac Surg 1995; 53:387-397.

Glueck CJ, McMahon RE, Bouquot JE, et al. Thrombophilia, hypofibrinolysis and osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol 1996; 81:557-566.

Gruppo R, Glueck CJ, McMahon RE, Bouquot J, Rabinovich BA, Becker A, Tracy T, Wang P. The pathophysiology of osteonecrosis of the jaw: anticardiolipin antibodies, thrombophilia, and hypofibrinolysis. J Lab Clin Med 1996; 127:481-488.

Bouquot JE, McMahon RE. Ischemic osteonecrosis in facial pain syndromes; A review of NICO (neuralgia-inducing cavitational osteonecrosis) based on experience with more than 2,000 patients. TMDiary 1996; 8:32-39. (invited review paper)

Glueck CJ, McMahon RE, Bouquot JE, Triplett DA, Gruppo R, Wang P. Heterozygosity for the Leiden mutation V gene, a common pathoetiology for osteonecrosis of the jaw with thrombophilia augmented by exogenous estrogens. J Lab Clin Med 1997; 130:540-543.

Glueck CJ, McMahon R, Bouquot J, Tracy T, Sieve-Smith L, Wang P. A preliminary pilot study of treatment of thrombophilia and hypofibrinolysis and amelioration of the pain of osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85:64-73.

McMahon RE, Bouquot JE, Glueck CJ. Exogenous estrogen may exacerbate thrombophilia, impair bone healing and contribute to development of chronic facial pain. J Craniomand Pract 1998; 16:143-153.

Bouquot JE, LaMarche MG. Ischemic osteonecrosis under fixed partial denture pontics: radiographic and microscopic features in 38 patients with chronic pain. J Prosthet Dent 1999; 81:148-158.

Adams WR, Spolnick KJ, Bouquot JE. Maxillofacial osteonecrosis in a patient with multiple facial pains. J Oral Pathol Med 1999; 28:423-432.

Bouquot JE, McMahon RE. Neuropathic pain in maxillofacial osteonecrosis (NICO). J Oral Maxillofac Surg 2000; in press. (invited review paper)

Bouquot JE, Griep J, Rabinovich S, Byron MA. Ischemic osteonecrosis of the jaws in 1,333 patients with facial pain -- an histopathologic review. Submitted for publication.


Published Abstracts, Letters, Etc.
[click on underlined author's name for more detail]

Bouquot JE, Roberts AM, Person P, Christian J. The histopathology of neuralgia-inducing cavitational osteonecrosis (NICO). J Dent Res 1989; 68:952. (abstract)

Bouquot J, Christian J. Long-term effects of jawbone curettage on the pain of facial neuralgia; treatment results in neuralgia-inducing cavitational osteonecrosis. Oral Surg Oral Med Oral Pathol 1991; 72:582. (abstract)

Bouquot JE. More on Neuralgia-inducing cavitational osteonecrosis, NICO (reply to letter to the editor). Oral Surg Oral Med Oral Pathol 1992; 74:348-350. (abstract)

Bouquot JE, Roberts A. NICO (neuralgia-inducing cavitational osteonecrosis): radiographic appearance of the "invisible" osteomyelitis. Oral Surg Oral Med Oral Pathol 1992; 74: 600. (abstract)

Bouquot JE. Ischemia and infarction of the jaws - the "phantom" pain of NICO. J Craniomand Pract 1994; 12:138-139. (invited guest editorial)

McMahon R, Bouquot J, Mahan P, Gremillion H. Elevated serum peripheral nerve anti-myelin antibody titers in atypical facial pain patients with NICO. J Orofacial Pain 1994; 8:104. (abstract)

Glueck CJ, McMahon RE, Bouquot JE, Rabinovich B. Hypofibrinolysis and thrombophilia, pathophysiologic etiologies of osteonecrosis of the jaws and atypical facial neuralgia. J Orofacial Pain, 1995; 9:103. (abstract)

Glueck CJ, McMahon RE, Bouquot JE, Stroop D, Trent T, Freiberg R, Wang S. Resistance to activated protein C, estrogens, and osteonecrosis of the jaws. J Invest Med 1995; 43 (suppl): 234A. (abstract)

Glueck CJ, Gruppo R, McMahon RE, Bouquot JE, Stroop D, Becker A, Tracy T, Wang P. Anticardiolipin antibodies and osteonecrosis of the jaws. J Invest Med 1995; 43 (suppl 3): 459A. (abstract)

Gruppo R, Glueck C, McMahon R, Bouquot J. Anticardiolipin antibodies, thrombophilia and hypofibrinolysis in Neuralgia-Inducing Cavitational Osteonecrosis of jaw. J Oral Maxillofac Surg 1995; 53(suppl): 84-85. (abstract)

McMahon R, Glueck C, Bouquot J, Rabinovich B. Protein C disorders are risk factors for alveolar osteonecrosis and chronic facial pain. J Oral Maxillofac Surg 1995; 53(suppl): 169-170. (abstract)

Bouquot J, McMahon R. Ischemic osteonecrosis of the jaws in 2,023 patients with facial pain. J Oral Pathol Med 1996; 25:271. (abstract)

Glueck CJ, McMahon RE, Bouquot J, Tracy T, Seive-Smith L, Wang P. Treatment of thrombophilia and hypofibrinolysis ameliorates osteonecrosis of the jaws. J Investig Med 1996; 44:375. (abstract)

Bouquot JE, McMahon RE. Ischemic alveolar osteonecrosis in 2,023 patients with chronic facial pain. J Orofacial Pain 1997; 11:180. (abstract)

Bouquot JE, McMahon RE. Ischemic osteonecrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 84:229-230. (letter to editor)

Glueck CJ, McMahon RE, Bouquot JE. The treatment of thrombophilia and hypofibrinolysis ameliorates the pain of osteonecrosis of the jaws. J Orofacial Pain 1997; 11:180. (abstract)

McMahon RE, Glueck CJ, Bouquot J. Protein C disorders are risk factors for alveolar osteonecrosis and chronic facial pain. J Orofacial Pain 1997; 11:179. (abstract)

McMahon RE, Glueck CJ, Bouquot JE, Triplett. The prevalence of factor V Leiden and methylene-tetrahydrofolate reductase (MTHFR) gene mutations in 87 patients with osteonecrosis of the jaws and chronic facial pain. J Orofacial Pain 1997; 11:179-180. (abstract)

Triplett, McMahon RE, Bouquot JE, Glueck CJ. The mutant factor V Leiden gene and thrombophilic resistance to activated protein C in patients with ischemic osteonecrosis of the jaws. J Orofacial Pain 1997; 11:179. (abstract)

Bouquot J, LaMarche M. Subpontic osteonecrosis: imaging and microscopic features in 38 patients with "idiopathic" chronic pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 86:209-210. (abstract)

Bouquot J, McMahon R. Bone marrow edema syndrome: new disease or early presentation of ischemic osteonecrosis? J Oral Pathol Med 1998; 27:346. (abstract)

McMahon R, Bouquot J, Mahan P, Saxen M. Elevated anti-myelin antibodies in patients with maxillofacial osteonecrosis (NICO). J Oral Pathol Med 1998; 27:345-346. (abstract)

Bouquot JE, LaMarche MG. Ischemic osteonecrosis under fixed partial denture pontics: radiographic and microscopic features in 38 patients with chronic pain. 2000 Yearbook of Dentistry. Year Book Med. Publ, Inc, Chicago, 2000; in press. (abstract of published paper)

Bouquot J, McMahon R. Bone marrow edema syndrome, independent disease or early presentation of ischemic osteonecrosis? Proceedings, Annual Meeting, American Academy of Oral & Maxillofacial Pathology; Williamsburg, Virginia; April, 2000. (abstract)

Bouquot J, McMahon R The hollow tuberosity – clinicopathologic review of 1057 biopsied cases. Proceedings, Biannual Congress, International Association of Oral Pathologists; La Antigua, Guatemala; September, 2000. (abstract)

Bouquot J, Wrobleski G, Fenton S. The most common osteonecrosis? Prevalence of maxillofacial osteonecrosis (MFO). Proceedings, Biannual Congress, International Association of Oral Pathologists; La Antigua, Guatemala; September, 2000. (abstract)


Book Chapters & Major Handouts
[click on underlined author's name for more detail]

Bouquot JE. NICO (neuralgia-inducing cavitational osteonecrosis) of the jawbones. In: Meinig GE. Root canal cover-up, 2nd ed. Ojai, California, Bion Publ.; 1994.

Bouquot JE. Facial pain and neuromuscular diseases. In: Neville B, Damm D, Allen C, Bouquot J. Oral & maxillofacial pathology. Philadelphia, W. B. Saunders; 1995:627-644.

Glueck CJ, Freiberg R, Gruppo R, Crawford A, Roy D, Brandt G, McMahon RE, Bouquot J, Tracy T, Stroop D, Wang P, Becker A. Thrombophilia and hypofibrinolysis: reversible pathogenetic etiologies of osteonecrosis. In: Urbaniak JR, Jones, JP Jr (eds). Osteonecrosis: etiology, diagnosis, and treatment. American Academy of Orthopaedic Surgeons; Chicago, Illinois; 1997:105-110.

Bouquot JE, McMahon RE. Maxillofacial osteonecrosis. Part I: A review of NICO.  Morgantown, West Virginia: The Maxillofacial Center, 1998:1-18. (handout)

Bouquot JE, McMahon RE. The pain of maxillofacial osteonecrosis. In: Haddox D (ed.). Orofacial pain -- guidelines for assessment, diagnosis, and management, 2nd edition. Chicago, Quintessence Publ, 2000: in press.